Hyaline droplet formation in the renal epithelium of patients with haemoglobinuria.

Hazard evaluation of chemicals that cause accumulation of alpha 2u-globulin, hyaline droplet nephropathy, and tubule neoplasia in the kidneys of male rats.

This review paper examines the relationship between chemicals inducing excessive accumulation of alpha 2u-globulin (alpha 2u-g) (CIGA) in hyaline droplets in male rat kidneys and the subsequent development of nephrotoxicity and renal tubule neoplasia in the male rat. This dose-responsive hyaline droplet accumulation distinguishes CIGA carcinogens from classical renal carcinogens. CIGA carcinoge...

Cellular Mechanisms of Protein Metabolism in the Nephron

1. The exaggeration of "hyaline droplet" formation observed in the renal lesion of epidemic hemorrhagic fever when treated with the infusion of large amounts of human serum albumin and the histochemical characteristics of the droplets so formed afford evidence towards their identification with the protein absorption droplets of experimental procedures and with those that occur in other renal di...

Kidney, Renal Tubule – Accumulation, Hyaline Droplet

Renal Medullary Carcinoma; A Rare Entity

AbstractRenal medullary carcinoma (RMC) is an uncommon aggressive neoplasm of the kidney. RMC is biologically aggressive with a very poor prognosis, and metastasis is seen in up to 95% of the patients at diagnosis or shortly thereafter. The common sites of metastasis are respectively lymph nodes, lungs, livers, and adrenal glands in order of frequency. The presence of poorly differentiated eosi...

Renal transplantation for end-stage renal disease due to paroxysmal nocturnal haemoglobinuria.

Paroxysmal nocturnal haemoglobinuria (PNH) is characterized by nocturnal haemoglobinuria, haemolytic anaemia, and thrombosis [ 1]. Most patients have anatomical and functional renal abnormalities, although renal function deterioration often remains unrecognized. The pathogenesis could be related to iron deposition or to repeated vascular thrombosis. The present case illustrates that renal trans...